Four Seasons San Francisco Hotel is located in the central South of Market district of San Francisco, 200 metres from Lotta's Fountain and Union Square. The Westfield San Francisco Center Shopping Center and the San Francisco Museum of Modern Art are nearby.

The restaurant offers a menu consisting of international dishes. There is also a bar. The hotel has an indoor pool, a spa center, a health club with a sauna and a Russian bath. The hotel's banquet and conference rooms are available for rent for various events. Wireless and wired internet access, a parking space, concierge assistance and translation services are available for an additional fee.

The rooms are equipped with cable or satellite TV, CD and DVD players and pay movies, as well as a minibar, air conditioning and a safe. Baby cots are available upon prior request.