Mercure Sydney Macquarie Park Hotel is located in Macquarie Park, near major business parks, adjacent to Macquarie University Hospital and Macquarie University, and next door to Macquarie Shopping Centre.

The hotel offers free luggage storage, a 24-hour front desk, a large outdoor area with restaurant seating, guest laundry, in-house all-day dining, bar, on-site outdoor parking, accessible rooms, and a bookable shuttle bus for around the local business park.

The hotel has 120 rooms with a private kitchenette, free Wi-Fi, LCD TV, ironing equipment, air conditioning, and a safe.